Thanks Jay,
I do run both compression and a number of other filters on the audio - including my own channel. In fact each guest is recorded on a separate channel, then filtered and edited and then remixed for the final.
One of the great challenges I have is that I'm running off a direct Heil PR-40 Studio Mic connected right into the digital mixer which gives a pretty rich sound, while the guests are generally using much less expensive headset mics that get compressed by skype. While often it comes out just fine, sometimes the guest's inexpensive mics sound a bit tinny - even with editing which makes mine sound quite a bit richer/louder by comparison.
Brad