Natural sugars (apples, oranges) have the least effect on me, processed sugars (the stuff you use in your coffee) have the biggest effect of all (I use honey in my coffee). So if a macro brewery uses sugar to "boost" og (they wouldn't do that would they?), I am affected, though I (not to date anyway) have not been affected by any brewpub in this way. I don't/can't drink sodas because of the sugars in them (Coke makes me want to sleep & gives me a headache... e.g. hangover). I stay away from candy bars most of the time.
This is the biggest reason I'm a beer drinker, Mixed drinks, like bourbon and coke, ruin my whole night. The sugars from the malt are "natural". Bourbon is "natural" also, but I can't drink it straight, or with water, and the concentration of sugar in fountain sodas is higher than bottles ones. I don't care for the flavor much in the first place.