I use 6-row when I make light pilsners with corn, but that's it. 6-row is slightly cheaper, but because the kernels are smaller you end up with more husks per weight. That and if you mill it yourself it might not grind properly if you're set up for 2-row. There really aren't any advantages to 6-row other than the higher enzyme content. If you're not using adjuncts, I can't think of any point in using it.